Preparative chromatography and introduction to process analysis

Instruction is in the form of lectures, exercises, laboratory sessions, seminars, and a project. Students

are expected to study certain units on their own.

The course comprises two modules: preparative chromatography for small and large molecules and process analysis. The preparative chromatography module also includes a project.

The preparative chromatography module covers the following:

• Introduction to equipment for chromatographic purification and processes at different scale, both batch and continual elution
• In-depth study of different separation mechanisms related to stationary phase chemistry, adsorption isotherms, column models, and process optimisation
• Introduction to numerical simulation of separation processes and the use of column models and adsorption models for calculation of design parameters for different separation processes
• Empirical and numerical modelling and optimisation of separation processes

The project included in the preparative chromatography module covers the following:

• Introduction to the use of chromatographic purification equipment
• Exercises in numerical and empirical optimisation of separation problems
• A project which includes selection of a separation problem, literature study, design of a separation strategy, calculations, experimental characterisation of the separation system (if applicable), optimisation of the separation, analysis of the results, a written report, and an oral presentation

All project components involve mandatory attendance and active participation.

The process analysis module covers the following:

• Introduction to common techniques and sensors used in PAT, plus related theories
• Sensor strategies and sampling strategies for measurements in process analysis
• Processing of sensor data using for instance chemometric methods

Laboratory sessions and seminars involve mandatory attendance and active participation.

Progressive specialisation: A1N (has only first‐cycle course/s as entry requirements)

Education level: Master's level

Admission requirements: A Bachelor degree in Chemistry or registered for 90 ECTS credits in Chemistry, with 75 ECTS credits completed, and upper secondary level Swedish 3 or Swedish as a second language 3 and English 6, or equivalent

Selection: Selection is usually based on your grade point average from upper secondary school or the number of credit points from previous university studies, or both.